Severity of Ventilation Impairment (PF ratio)

Severity of Ventilation Impairment (PF ratio)

What is the PF ratio?

  • PaO2/FiO2 is the ratio of arterial oxygen partial pressure to fractional inspired oxygen – aka the Carrico or Horrowitz index and the PF ratio.
  • It is a widely used clinical indicator of hypoxaemia, at sea level, it is normally > 500mmHg.
  • Mild – PF ratio 200-300mmHg
  • Moderate – PF ratio 100-200mmHg
  • Severe – PF ratio <100mmHg
Many online calculators are available online, this is one such example:

Frailty and Co-morbidity

Frailty and Co-morbidity

Not all co-morbidities correlate to poor clinical outcome, the Clinical Frailty Score (CFS) aligns with prognosis. Scores of 5 and above suggest minimal benefit with Critical Care interventions e.g. Intubation, mechanical ventilation. Assess each patient on their own merits using the following structure:
  • Their overall level of physical fitness
  • The presence or absence of any active disease symptoms (for example, well-controlled diabetes will impact frailty status much less than diabetes with complications like nerve, eye or heart problems)
  • Their level of dependency on other people for their activities of daily living (ADLs)
  • Their cognitive status

Critical Care Escalation

Critical Care Escalation

Patients may not improve despite optimal NIV setup, good medical and nursing care. In such situations, early critical care review is essential. Reminder: refer to ITU if not improving 1 hour after CPAP initiation for consideration of IMV if for full escalation and for daily ICU discussion if not improving on NIV. There are special circumstances when NIV is not appropriate, these include:
  • Severe type 2 respiratory failure with pH <7.25
  • Severe pneumonia
  • Acute severe asthma (NEVER use NIV)